منابع مشابه
Sickle cell trait: not as benign as once thought
We describe a case of renal papillary necrosis in a middle-aged female with sickle cell trait who presented with gross hematuria. We wish to highlight this case for several reasons. Sickle cell trait is often viewed as a benign condition despite the fact that it is associated with significant morbidity such as renal papillary necrosis and renal medullary carcinoma. Appropriate evaluation needs ...
متن کاملHow benign is sickle cell trait?
The complications of sickle cell disease (SCD) arise from the presence in red cells of the mutated haemoglobin, HbS, which replaces the normal adult Hb,HbA. HbS has a single amino acid substitutionwhereby valine replaces glutamic acid in the 6th codon of the β chain. Most SCD patients inherit two copies of the sickle gene (homozygous HbSS individuals sometimes termed sickle cell anaemia, SCA). ...
متن کاملSickle Cell Trait: A Benign State?
BACKGROUND Sickle cell trait (SCT) is the heterozygous form of sickle cell disease and expectedly should be a benign state with no complications ascribed to it. There are numerous reports challenging its being a benign condition, though this is controversial. METHODS AND RESULTS A review of the results of the accompanying investigations done on some of the patients show that beta thalassemia ...
متن کاملSickle cell trait.
Sickle cell trait can pose a grave risk for some athletes. In the past few years, exertional sickling has killed nine athletes, including five college football players in training. Exercise-physiology research shows how and why sickle red cells can accumulate in the bloodstream during intense exercise bouts. Sickle cells can "logjam" blood vessels and lead to collapse from ischemic rhabdomyolys...
متن کاملHigh Foetal Haemoglobin in Sickle Cell Disease: Not so Protective?
Sickle cell disease (SCD) comprises a group of genetic disorders in before one year of age in SCA and the adhesion of reticulocytes to the which the red blood cells (RBCs) produce abnormal sickle haemoglobin (HbS) that can polymerise when oxygen concentrations are low. The clinical manifestations of SCD are numerous, and vary from patient to patient, but recurrent vaso-occlusive processes can c...
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ژورنال
عنوان ژورنال: BMJ
سال: 1963
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.5371.1534